ChloroquineV1, Main, Exploration, bibRecord, 000382

Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis.

Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383

Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis.

Auteurs : Richa Mishra [Inde] ; Sakshi Kohli [Inde] ; Nitish Malhotra [Inde] ; Parijat Bandyopadhyay [Inde] ; Mansi Mehta [Inde] ; Mohamedhusen Munshi [Inde] ; Vasista Adiga [Inde] ; Vijay Kamal Ahuja [Inde] ; Radha K. Shandil [Inde] ; Raju S. Rajmani [Inde] ; Aswin Sai Narain Seshasayee [Inde] ; Amit Singh [Inde]

Source :

Science translational medicine [ 1946-6242 ] ; 2019.

RBID : pubmed:31723039

Abstract

The capacity of Mycobacterium tuberculosis (Mtb) to tolerate multiple antibiotics represents a major problem in tuberculosis (TB) management. Heterogeneity in Mtb populations is one of the factors that drives antibiotic tolerance during infection. However, the mechanisms underpinning this variation in bacterial population remain poorly understood. Here, we show that phagosomal acidification alters the redox physiology of Mtb to generate a population of replicating bacteria that display drug tolerance during infection. RNA sequencing of this redox-altered population revealed the involvement of iron-sulfur (Fe-S) cluster biogenesis, hydrogen sulfide (H₂S) gas, and drug efflux pumps in antibiotic tolerance. The fraction of the pH- and redox-dependent tolerant population increased when Mtb infected macrophages with actively replicating HIV-1, suggesting that redox heterogeneity could contribute to high rates of TB therapy failure during HIV-TB coinfection. Pharmacological inhibition of phagosomal acidification by the antimalarial drug chloroquine (CQ) eradicated drug-tolerant Mtb, ameliorated lung pathology, and reduced postchemotherapeutic relapse in in vivo models. The pharmacological profile of CQ (C_max and AUC_last) exhibited no major drug-drug interaction when coadministered with first line anti-TB drugs in mice. Our data establish a link between phagosomal pH, redox metabolism, and drug tolerance in replicating Mtb and suggest repositioning of CQ to shorten TB therapy and achieve a relapse-free cure.

DOI: 10.1126/scitranslmed.aaw6635
PubMed: 31723039

Affiliations:

Inde

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting redox heterogeneity to counteract drug tolerance in replicating <i>Mycobacterium tuberculosis</i>
.</title>
<author><name sortKey="Mishra, Richa" sort="Mishra, Richa" uniqKey="Mishra R" first="Richa" last="Mishra">Richa Mishra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kohli, Sakshi" sort="Kohli, Sakshi" uniqKey="Kohli S" first="Sakshi" last="Kohli">Sakshi Kohli</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malhotra, Nitish" sort="Malhotra, Nitish" uniqKey="Malhotra N" first="Nitish" last="Malhotra">Nitish Malhotra</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bandyopadhyay, Parijat" sort="Bandyopadhyay, Parijat" uniqKey="Bandyopadhyay P" first="Parijat" last="Bandyopadhyay">Parijat Bandyopadhyay</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehta, Mansi" sort="Mehta, Mansi" uniqKey="Mehta M" first="Mansi" last="Mehta">Mansi Mehta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munshi, Mohamedhusen" sort="Munshi, Mohamedhusen" uniqKey="Munshi M" first="Mohamedhusen" last="Munshi">Mohamedhusen Munshi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adiga, Vasista" sort="Adiga, Vasista" uniqKey="Adiga V" first="Vasista" last="Adiga">Vasista Adiga</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahuja, Vijay Kamal" sort="Ahuja, Vijay Kamal" uniqKey="Ahuja V" first="Vijay Kamal" last="Ahuja">Vijay Kamal Ahuja</name>
<affiliation wicri:level="1"><nlm:affiliation>Foundation for Neglected Disease Research, Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Foundation for Neglected Disease Research, Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shandil, Radha K" sort="Shandil, Radha K" uniqKey="Shandil R" first="Radha K" last="Shandil">Radha K. Shandil</name>
<affiliation wicri:level="1"><nlm:affiliation>Foundation for Neglected Disease Research, Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Foundation for Neglected Disease Research, Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajmani, Raju S" sort="Rajmani, Raju S" uniqKey="Rajmani R" first="Raju S" last="Rajmani">Raju S. Rajmani</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seshasayee, Aswin Sai Narain" sort="Seshasayee, Aswin Sai Narain" uniqKey="Seshasayee A" first="Aswin Sai Narain" last="Seshasayee">Aswin Sai Narain Seshasayee</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Singh, Amit" sort="Singh, Amit" uniqKey="Singh A" first="Amit" last="Singh">Amit Singh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India. asingh@iisc.ac.in.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31723039</idno>
<idno type="pmid">31723039</idno>
<idno type="doi">10.1126/scitranslmed.aaw6635</idno>
<idno type="wicri:Area/PubMed/Corpus">000025</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000025</idno>
<idno type="wicri:Area/PubMed/Curation">000025</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000025</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000024</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000024</idno>
<idno type="wicri:Area/Ncbi/Merge">000C05</idno>
<idno type="wicri:Area/Ncbi/Curation">000C05</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C05</idno>
<idno type="wicri:Area/Main/Merge">000382</idno>
<idno type="wicri:Area/Main/Curation">000382</idno>
<idno type="wicri:Area/Main/Exploration">000382</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Targeting redox heterogeneity to counteract drug tolerance in replicating <i>Mycobacterium tuberculosis</i>
.</title>
<author><name sortKey="Mishra, Richa" sort="Mishra, Richa" uniqKey="Mishra R" first="Richa" last="Mishra">Richa Mishra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kohli, Sakshi" sort="Kohli, Sakshi" uniqKey="Kohli S" first="Sakshi" last="Kohli">Sakshi Kohli</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malhotra, Nitish" sort="Malhotra, Nitish" uniqKey="Malhotra N" first="Nitish" last="Malhotra">Nitish Malhotra</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bandyopadhyay, Parijat" sort="Bandyopadhyay, Parijat" uniqKey="Bandyopadhyay P" first="Parijat" last="Bandyopadhyay">Parijat Bandyopadhyay</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehta, Mansi" sort="Mehta, Mansi" uniqKey="Mehta M" first="Mansi" last="Mehta">Mansi Mehta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munshi, Mohamedhusen" sort="Munshi, Mohamedhusen" uniqKey="Munshi M" first="Mohamedhusen" last="Munshi">Mohamedhusen Munshi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adiga, Vasista" sort="Adiga, Vasista" uniqKey="Adiga V" first="Vasista" last="Adiga">Vasista Adiga</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahuja, Vijay Kamal" sort="Ahuja, Vijay Kamal" uniqKey="Ahuja V" first="Vijay Kamal" last="Ahuja">Vijay Kamal Ahuja</name>
<affiliation wicri:level="1"><nlm:affiliation>Foundation for Neglected Disease Research, Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Foundation for Neglected Disease Research, Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shandil, Radha K" sort="Shandil, Radha K" uniqKey="Shandil R" first="Radha K" last="Shandil">Radha K. Shandil</name>
<affiliation wicri:level="1"><nlm:affiliation>Foundation for Neglected Disease Research, Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Foundation for Neglected Disease Research, Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajmani, Raju S" sort="Rajmani, Raju S" uniqKey="Rajmani R" first="Raju S" last="Rajmani">Raju S. Rajmani</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seshasayee, Aswin Sai Narain" sort="Seshasayee, Aswin Sai Narain" uniqKey="Seshasayee A" first="Aswin Sai Narain" last="Seshasayee">Aswin Sai Narain Seshasayee</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065</wicri:regionArea>
<wicri:noRegion>Bangalore 560065</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Singh, Amit" sort="Singh, Amit" uniqKey="Singh A" first="Amit" last="Singh">Amit Singh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India. asingh@iisc.ac.in.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012</wicri:regionArea>
<wicri:noRegion>Bangalore 560012</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Science translational medicine</title>
<idno type="eISSN">1946-6242</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The capacity of <i>Mycobacterium tuberculosis</i>
 (<i>Mtb</i>
) to tolerate multiple antibiotics represents a major problem in tuberculosis (TB) management. Heterogeneity in <i>Mtb</i>
 populations is one of the factors that drives antibiotic tolerance during infection. However, the mechanisms underpinning this variation in bacterial population remain poorly understood. Here, we show that phagosomal acidification alters the redox physiology of <i>Mtb</i>
 to generate a population of replicating bacteria that display drug tolerance during infection. RNA sequencing of this redox-altered population revealed the involvement of iron-sulfur (Fe-S) cluster biogenesis, hydrogen sulfide (H<sub>2</sub>
S) gas, and drug efflux pumps in antibiotic tolerance. The fraction of the pH- and redox-dependent tolerant population increased when <i>Mtb</i>
 infected macrophages with actively replicating HIV-1, suggesting that redox heterogeneity could contribute to high rates of TB therapy failure during HIV-TB coinfection. Pharmacological inhibition of phagosomal acidification by the antimalarial drug chloroquine (CQ) eradicated drug-tolerant <i>Mtb</i>
, ameliorated lung pathology, and reduced postchemotherapeutic relapse in in vivo models. The pharmacological profile of CQ (<i>C</i>
<sub>max</sub>
 and AUC<sub>last</sub>
) exhibited no major drug-drug interaction when coadministered with first line anti-TB drugs in mice. Our data establish a link between phagosomal pH, redox metabolism, and drug tolerance in replicating <i>Mtb</i>
 and suggest repositioning of CQ to shorten TB therapy and achieve a relapse-free cure.</div>
</front>
</TEI>
<affiliations><list><country><li>Inde</li>
</country>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Mishra, Richa" sort="Mishra, Richa" uniqKey="Mishra R" first="Richa" last="Mishra">Richa Mishra</name>
</noRegion>
<name sortKey="Adiga, Vasista" sort="Adiga, Vasista" uniqKey="Adiga V" first="Vasista" last="Adiga">Vasista Adiga</name>
<name sortKey="Ahuja, Vijay Kamal" sort="Ahuja, Vijay Kamal" uniqKey="Ahuja V" first="Vijay Kamal" last="Ahuja">Vijay Kamal Ahuja</name>
<name sortKey="Bandyopadhyay, Parijat" sort="Bandyopadhyay, Parijat" uniqKey="Bandyopadhyay P" first="Parijat" last="Bandyopadhyay">Parijat Bandyopadhyay</name>
<name sortKey="Kohli, Sakshi" sort="Kohli, Sakshi" uniqKey="Kohli S" first="Sakshi" last="Kohli">Sakshi Kohli</name>
<name sortKey="Malhotra, Nitish" sort="Malhotra, Nitish" uniqKey="Malhotra N" first="Nitish" last="Malhotra">Nitish Malhotra</name>
<name sortKey="Mehta, Mansi" sort="Mehta, Mansi" uniqKey="Mehta M" first="Mansi" last="Mehta">Mansi Mehta</name>
<name sortKey="Munshi, Mohamedhusen" sort="Munshi, Mohamedhusen" uniqKey="Munshi M" first="Mohamedhusen" last="Munshi">Mohamedhusen Munshi</name>
<name sortKey="Rajmani, Raju S" sort="Rajmani, Raju S" uniqKey="Rajmani R" first="Raju S" last="Rajmani">Raju S. Rajmani</name>
<name sortKey="Seshasayee, Aswin Sai Narain" sort="Seshasayee, Aswin Sai Narain" uniqKey="Seshasayee A" first="Aswin Sai Narain" last="Seshasayee">Aswin Sai Narain Seshasayee</name>
<name sortKey="Shandil, Radha K" sort="Shandil, Radha K" uniqKey="Shandil R" first="Radha K" last="Shandil">Radha K. Shandil</name>
<name sortKey="Singh, Amit" sort="Singh, Amit" uniqKey="Singh A" first="Amit" last="Singh">Amit Singh</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000382 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000382 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31723039
   |texte=   Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31723039" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis.

Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.